Approaches in activating NRF2, such as administration of the NRF2 activator sulforaphane (SFN) [5, 6], supplementation of zinc [15], and exposure to low-dose X-irradiation [8], effectively ameliorated diabetes-induced testicular inflammation, ER stress, and apoptotic cell death, in rodent models of both type 1 and type 2 diabetes. Here, NFE2L2 is linked to diabetes mellitus.