AKT1 and hepatocellular carcinoma: We examined the p-AKT and PTEN expression levels in HCC cells after treatment with H2S and found that 25–50 μM NaHS up-regulated AKT phosphorylation, and 25–100 μM NaHS decreased PTEN expression; however, 800–1000 μM NaHS dose-dependently reduced AKT phosphorylation and increased PTEN expression.