As mentioned above, we enrolled 504 SNPs in the first stage, a total of 16 interactional SNPs were found remarkably associated with chemotherapy response or toxicities in this cohort (Fig. 1 and supplementary Table S3) We found that the paired interaction between SLC2A1 rs4658 and HSPD1 rs17730989 was significantly associated with platinum-based chemotherapy response in NSCLC patients (adjusted OR = 5.430, P = 2.610 × 10−5), indicating the two-locus model of SLC2A1 rs4658-HSPD1 rs17730989 might be related to drug sensitivity. This evidence concerns the gene SLC2A1 and non-small cell lung carcinoma.