By genomic profiling of prostate cancer bone metastatic samples, we found a common genomic deletion at 6q16.1–16.2 and through further investigations we identified the FBXL4 gene, located within this 6q16.1–16.2 region, as the putative TSG in regulating prostate cancer bone metastases. The gene discussed is FBXL4; the disease is Familial prostate cancer.