FBXL4 and benign prostatic hyperplasia: To investigate if loss of FBXL4 genomic region also occurs at early stage of prostate cancer development, we analysed 145 primary cancer samples by FISH and detected FBXL4 genomic loss in 20 cases (13.8%), but not in any of the 55 BPH cases used as non-neoplastic controls (Fig. 1c).