Involvement of F-box proteins in controlling cancer spread and metastasis is common and can encompass different mechanisms such as resistance to anoikis, a type of detachment-induced apoptosis affecting tumour cells detached from primary mass (SKP2 oncogene ref. 42), inhibition of niche formation at distant metastatic site (FBXW7 TSG ref. 43) or modulates cellular stress response and metastatic potential (FBXW7 TSG ref. 44). The gene discussed is SKP2; the disease is cancer.