FBXL4 and prostate cancer: Although mutations in FBXL4 may occur, they are uncommon (https://icgc.org/ and http://cancer.sanger.ac.uk/) and in a recent exome sequencing study of 150 metastatic castration-resistant prostate cancer, only two point mutations were found in FBXL4, while deletion of this genomic region was detected in 20% of samples16.