Of particular interest, pathway enrichment analysis of the 34 common gene associated DMRs revealed epigenetic impairment of NRF2 oxidative stress (SOD2), DNA repair (BRCA1), thioredoxin (TXNRD1) and inflammatory pathways (MIF, PLA2G4D) in atherosclerosis conditions. The gene discussed is BRCA1; the disease is atherosclerosis.