We show that TDRD3 promotes the expression of a number of genes known to be crucial players in the EMT process in breast cancer cells, including SNAI1, SNAI2, CTNNB1 and VIM. Lastly, we demonstrate, for the first time, that TDRD3 regulates the expression of at least some of these genes at the level of translation. This evidence concerns the gene SNAI2 and breast carcinoma.