The results showed that Exo70 expression was dramatically associated with colon cancer patients’ overall survival; the mean OS was 88.6 months in the slightly positive (+) Exo70 expression group and 65.1 months in the moderately positive (++) Exo70 expression group, whereas it was only 41.1 months in the strongly positive (+++) Exo70 expression group. The gene discussed is EXOC7; the disease is malignant colon neoplasm.