Forty genes were upregulated in the MD group, such as laminin subunit beta 2 (LAMB2), collagen type VI alpha 5 chain (COL6A5), hyaluronan mediated motility receptor (HMMR), etc. Six genes, syndecan 1 (SDC1), secreted phosphoprotein 1 (SPP1), integrin subunit beta 3 (ITGB3), etc., were upregulated in the ME group. This evidence concerns the gene COL6A5 and Menkes disease.