The mutations in epigenetic modifiers, such as isocitrate dehydrogenase (IDH1/2), telomerase reverse transcriptase (TERT), and alpha-thalassemia/mental retardation syndrome X-linked (ATRX), which lead to global changes in the epigenome, are common drivers of gliomagenesis [2,3]. The gene discussed is TERT; the disease is Alpha-thalassemia.