At the same time, antioxidant systems are defective in CKD [38,39,40,41], but we recently described that nuclear factor erythroid 2-related factor 2 (NRF-2) and one of its target genes, superoxide dismutase (SOD) 2, are upregulated in dialysis-treated patients, defining a possible antioxidant system able to contrast ROS production. Here, NFE2L2 is linked to chronic kidney disease.