Ubiquitin–proteasome system (UPS) dysregulation is linked to a number of inherited and acquired diseases such as cancer, diabetes, stroke, graft injection, Alzheimer’s disease, amyotropic lateral sclerosis, multiple sclerosis, asthma, inflammatory bowel disease, autoimmune thyroiditis, inflammatory arthritis, and systemic lupus erythematosus [70,71]. This evidence concerns the gene UBC and Alzheimer disease.