ESR1 and breast cancer: Further stratified analyses found that soy intake during adulthood was significantly associated with decreased risk of ER−/PR− breast cancer in premenopausal women (HR = 0.46; 95% CI = 0.22–0.97) and decreased risk of ER+/PR+ breast cancer in postmenopausal women (HR = 0.72; 95% CI = 0.53–0.96).