CASP8 and breast cancer: To be specific, SFN activated apoptosis in MDA-MB-231 cells through induction of Fas ligand which led to activation of caspase-8, caspase-3 and poly (ADPribose) polymerase, while SFN induced apoptosis in the other breast cancer cell lines by reduction of Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-3 and caspase-9, but not caspase-8, and poly (ADP-ribose) polymerase cleavage [170].