In a study, twelve xanthone constituents were isolated from the pericarp of mangosteen, among which α-mangostin, γ-mangostin, garcinone D, and garcinone E, showed dose-dependent anti-aromatase activity in SK-BR-3 breast cancer cells, with γ-mangostin being the most potent [104]. The gene discussed is CYP19A1; the disease is breast cancer.