This study noted the induction of ATF3, EGR1, JUNB, IRF7, ISG15, HERC5/6, additional ISGs, chemokines CCL5 and CXCL10, prosurvival responses, and decreased proapoptotic genes, similar to gene induction levels we found to be induced by ZIKV infection of hBMECs (Table 1) (GEO GSE98889). This evidence concerns the gene ISG15 and Zika virus infectious disease.