IRF5 is expressed by monocytes, macrophages, conventional dendritic cells, plasmacytoid dendritic cells, B cells, and some stromal cells.40 Although the expression of IRF5 within mouse and human atherosclerotic lesions appeared to be confined to myeloid cells, our data (obtained with a global genetic deletion of IRF5) cannot exclude indirect effects arising from the deletion of IRF5 in other cell types and thus is a limitation of our study. The gene discussed is IRF5; the disease is Atherosclerotic lesion.