To clarify the clinical relevance of CTHRC1 expression in breast cancer, we performed IHC on breast cancer tissues of 121 breast cancer patients with tissue microarray, and then patients were dichotomized according to low (IRS ≤ 4) or high (IRS > 4) expression of CTHRC1 (Fig. 2a). This evidence concerns the gene CTHRC1 and breast cancer.