CTHRC1 and breast cancer: We also found high CTHRC1 expression was significantly associated with poor OS (RR = 3.04, 95% CI = [1.70, 5.47], P = 0.0002, fixed-effect) and RFS (RR = 2.64, 95% CI = [1.68, 4.16], P < 0.0001, fixed-effect) in breast cancer patients (Fig. 2c).