KDM1A and non-small cell lung carcinoma: GSK-LSD1, a selective chemical probe for the histone lysine demethylase KDM1A (LSD1) (Structural Genomics Consortium, 2017), and the irreversible EGFR-mutant selective kinase inhibitor osimertinib (now approved in non-small-cell lung cancer), exemplify this approach (Finlay et al., 2014).