KRAS and cancer: Furthermore, chloroquine, a lysosomotropic agent commonly used as a claimed chemical probe to inhibit autophagy function, and also a more potent analog thereof, were shown to elicit antiproliferative effects in KRAS-mutant cancer cell lines in the absence of a functioning autophagy pathway, thereby devalidating the hypothesis that KRAS-mutant tumors are addicted to autophagy and devalidating chloroquine as a chemical probe for interrogating autophagy function (Eng et al., 2016).