IGHE and allergic disease: However, nonsynonymous mutations were identified in the coding sequences of Cer1, Ttc39b, Ccdc171, Cntln, Adamtsl1, Haus6, Gm12551, and Dennd4c, but these genes do not have any prior documented associations with allergy, IgE, or asthma (Eppig et al. 2012).