Consequently, we analyzed the effects of all CACNA1C variants and adult trauma on current depression symptoms, determined by the Beck Depression Inventory59 in a large African American cohort of non-psychiatric clinical patients (n=4808) from the Grady trauma project.49, 50, 60 Importantly, symptoms of depression are not only characteristic for MDD and BPD but can also occur as part of affective dysregulation in SCZ24. This evidence concerns the gene CACNA1C and major depressive disorder.