Chronic stress and/or trauma represent strong risk factors for a number of psychiatric disorders, including MDD, BPD and anxiety disorders such as post-traumatic stress disorder.24, 25, 26, 57 In view of the phenotype in Cav1.2-DevGlu-CKO mice, we wondered whether developmental deletion of Cacna1c would increase the susceptibility to CSDS. This evidence concerns the gene CACNA1C and major depressive disorder.