Moreover, insulin also suppresses the expression of ADAM metallopeptidase domain 33 (ADAM-33), TNF superfamily member 14 (LIGHT), and lymphotoxin beta receptor (LTBR), and reduces the plasma concentrations of plasma concentration of nitric oxide metabolites (NOM), LIGHT, transforming growth factor beta 1 (TGF-β1), C–C motif chemokine ligand 2 (MCP-1), and matrix metallopeptidase 9 (MMP-9), all associated with asthma [42]. The gene discussed is INS; the disease is asthma.