CHI3L1 and obesity due to melanocortin 4 receptor deficiency: In addition, higher Chi3l1 levels (168 ± 71.5 ng/mL) were associated with obesity-related asthma than with early-onset atopic and late-onset non-atopic phenotypes (80.62 ± 46.9 and 51.5 ± 24.9 ng/mL, respectively) [44].