APP and Alzheimer disease: Moreover, both Aβ and Tau can bind to amyloid precursor protein (APP) (Lorenzo et al., 2000; Van Nostrand et al., 2002; Shaked et al., 2006; Fogel et al., 2014; Takahashi et al., 2015), a protein with a central role in AD pathogenesis that might act as a cell surface receptor (Deyts et al., 2016).