Numerous studies have demonstrated that APC loss and/or WNT pathway activation can initiate tumour development in the mammalian intestine1, 2, 3, 4, 5, and we recently showed that re-engaging endogenous Wnt regulation via Apc restoration is sufficient to induce complete and sustained tumour regression, even in cancers carrying potent oncogenic mutations in Kras and p53 (ref. 6). Here, TP53 is linked to neoplasm.