KRAS and neoplasm: Numerous studies have demonstrated that APC loss and/or WNT pathway activation can initiate tumour development in the mammalian intestine1, 2, 3, 4, 5, and we recently showed that re-engaging endogenous Wnt regulation via Apc restoration is sufficient to induce complete and sustained tumour regression, even in cancers carrying potent oncogenic mutations in Kras and p53 (ref. 6).