While induction of the Bcan-Ntrk1 rearrangement readily resulted in high-grade gliomas, we never observed tumours after implantation of Fgfr3-Tacc3, Sec61g-Egfr or Gga2-Prkcb positive cell populations within the timeframe of analysis (150 days). Here, TACC3 is linked to central nervous system cancer.