Although we did not observe glioma formation even after inducing the Fgfr3-Tacc3 rearrangement directly in the brain of p53f/f mice using recombinant adenoviruses (Ad-FT, Supplementary Fig. 8), it is formally possible that the failure to induce Fgfr3-Tacc3-positive tumours reflects the inability of our adenoviral vector to infect the relevant cell of origin. This evidence concerns the gene TACC3 and central nervous system cancer.