Treatment of these tumour lines with nanomolar concentrations of entrectinib (RXDX 101), an investigational Trk inhibitor29, 30, resulted in reduced cell viability and inhibition of Akt and Erk phosphorylation in Bcan-Ntrk1-positive glioma lines, but not in a control glioma line generated by ectopically expressing PDGFb (Fig. 4a,b)31. The gene discussed is AKT1; the disease is glioma.