LGALS3 and cancer: Gal-3 is a pleiotropic carbohydrate-binding protein that can be located intracellular or secreted, whose expression is HIF1α-inducible (Greijer et al., 2005), is a known angiogenic factor (Markowska et al., 2010; Nangia-Makker et al., 2000), and frequently has altered expression in cancer (Thijssen et al., 2015).