IFNG and neoplasm: In addition to the in vitro experiments demonstrating that DFT1 cells upregulate MHC class I in response to IFNγ, DFT1 cells in tumour biopsies have been found that express β2m when clusters of CD3-positive leukocytes are adjacent, implying a response to IFNγ or other inflammatory cytokines (Siddle et al. 2013).