The continuous interactions between KIR2DS1 and self C2+ HLA-C molecules in resting state, however, leads to hypo responsiveness, so that the subset of KIR2DS1+ NK cells will be educated to be anergic in individuals who carry C2+ HLA-C allotypes, perhaps to avoid autoimmunity (Fig. 2). This evidence concerns the gene HLA-C and Autoimmunity.