The study conducted by Yoshikawa et al. [29] issued that similar to the phenotype observed in osteocalcin-deficient mice, partial ablation of osteoblasts in adult mice fallouts in metabolic abnormalities such as hypoinsulinemia, hyperglycemia, glucose intolerance, and decreased insulin sensitivity, mainly reversed by undercarboxylated osteocalcin injection. Here, INS is linked to Glucose intolerance.