BGLAP and Hypoinsulinemia: The study conducted by Yoshikawa et al. [29] issued that similar to the phenotype observed in osteocalcin-deficient mice, partial ablation of osteoblasts in adult mice fallouts in metabolic abnormalities such as hypoinsulinemia, hyperglycemia, glucose intolerance, and decreased insulin sensitivity, mainly reversed by undercarboxylated osteocalcin injection.