In a study using type 1 diabetic mice, renal CTGF and PAI-1 gene expressions were augmented by the activation of histone acetylation and HAT activity, as well as the enrichment of H3K9/14Ac and HAT p300/CBP at the promoters of CTGF and PAI-1 gene [64]. The gene discussed is EP300; the disease is type 1 diabetes mellitus.