This manifestation is known as “metabolic memory.” In the Diabetes Control and Complications Trial (DCCT), wherein conventional versus intensive insulin therapy were compared in type I diabetic patients, it was observed that intensive insulin regimen reduced the incidence or severity of diabetic renopathy, peripheral neuropathy, and retinopathy compared to patients who were on nonintensive insulin therapy [35]. The gene discussed is INS; the disease is retinal disorder.