EP300 and diabetes mellitus: In type 1 diabetic mice, diabetes-induced increases in histone acetylation and HAT activity, as well as the enrichment of H3K9/14Ac and HAT p300/CBP at the fibrotic gene promoters contributed to the upregulation of the expression of fibrotic genes that were significantly and persistently attenuated by a novel curcumin analog C66 treatment [64].