In a study using type 1 diabetic mice, renal CTGF and PAI-1 gene expressions were augmented by the activation of histone acetylation and HAT activity, as well as the enrichment of H3K9/14Ac and HAT p300/CBP at the promoters of CTGF and PAI-1 gene [64]. Here, CREBBP is linked to type 1 diabetes mellitus.