EP300 and type 1 diabetes mellitus: In another study, it was noted that renal fibronectin-1 (FN-1) gene expression in type 1 diabetic mice was augmented by the enrichment of H3K9/14Ac and HAT p300/CBP at the promoters of the FN-1 gene, which would lead to the development of renal fibrosis and expression of DKD [64].