A theoretic scenario is proposed that C-allele-dependent enzymatic loss of PNPLA3 hampers the TG transportation from hepatocytic lipid droplets to adipose tissues, with clinical features of liver steatosis and lowered serum level of TG, and then protects subjects from progressive obesity [35, 36, 39–41]. The gene discussed is PNPLA3; the disease is obesity due to melanocortin 4 receptor deficiency.