PNPLA3 rs738409 C>G among these ones induces adiponutrin variant of I148M, an isoleucine-to-methionine substitution with reduced activity of triglyceride (TG) hydrolysis, and predisposes normal populations (Chinese, Japanese, Korean, Filipino, Indian, Turk, Belgian, Mexican, American, and so forth) to hepatic steatosis [6, 17–22]. The gene discussed is PNPLA3; the disease is Hepatic steatosis.