All samples derived from mock (n = 4), MV-CD133 (n = 2), and MVPwt-CD133 (n = 4) treated animals were able to produce spheres ex vivo, whereas this was the case for only three out of four tumor specimens of MV-CD46/CD133-treated animals (n = 4) and only half, i.e., two, of the tumors treated with MVSCD-CD133 (n = 4). The gene discussed is CD46; the disease is neoplasm.