TMPRSS3 and Hearing impairment: We observed that four combinations of TMPRSS3 mutations resulted in prelingual, profound hearing impairment: c.1250G>A (p.Gly417Glu) and c.916G>A (p.Ala306Thr), c.1204G>A (p.Gly402Arg) and c.916G>A (p.Ala306Thr), c.809T>A (p.Ile270Asn) and c.916G>A (p.Ala306Thr), and c.1151T>G (p.Met384Arg) and c.1244T>C (p.Leu415Ser).