TMPRSS3 and deafness: The frequency of TMPRSS3 mutations in childhood ARNSHL cases was 12% (3/25) in Turkish families negative for GJB2 mutations [5]; 13.1% (5/38) in Slovenian ARNSHL patients negative for GJB2, GJB6, and mitochondrial A1555G mutations [6]; and 0.45% (2/448) in a European population with childhood deafness negative for the GJB2 35delG mutation [7].