NF1 and attention deficit-hyperactivity disorder: Work in heterozygous NF1 knockout mice in which the MAP kinase pathway was over-activated in neurons of the amygdala and frontal cortex, showed a selective social learning deficit and disruption to GABA and glutamatergic neurotransmission [86]; this study further implicates effects on excitatory and inhibitory neurotransmitter systems as being key to ADHD-related phenotypes in NF1.