EFHC2 and Timothy syndrome: Deletion mapping in TS has also revealed a small dosage-sensitive locus at Xp11.3 that is linked to impaired emotion recognition and increased orbitofrontal cortex grey matter and amygdala size [63]; follow-up genetic association analyses have implicated a variant within the EFHC2 gene in these phenotypes in both females with TS and healthy males [64, 65], although the data from TS is somewhat controversial [66].