Chin et al. reported that plant MIR159 was predominantly detected in Western human sera, with the abundance of this miRNA in the serum being inversely correlated with breast cancer incidence and progression in patients; they further showed that oral administration of a MIR159 mimicked significantly suppressed the growth of xenograft breast tumors in mice by targeting TCF7 [19]. Here, TCF7 is linked to breast neoplasm.