In addition, prohealing M2 MPs recently showed a facilitating factor for tissue angiogenesis via secreting vascular endothelial growth factor (VEGF), interleukin (IL) 10, and TGF-β in a myocardial infarction model as angiogenesis was critical for nutrient supply and regeneration support during the entire repair process [26, 27]. The gene discussed is VEGFA; the disease is myocardial infarction.