CD4 and cardiovascular disorder: It has also been shown in other studies of very old cohorts that increased HCMV IgG levels and differentiated CD4+ T cells are associated with elderly individuals in poor health (27), and there are also a number of studies associating HCMV seropositivity and higher HCMV IgG titers with poor outcomes from cardiovascular disease (14, 15, 17, 18).