Hematoxylin- and eosin-stained kidney sections from Hb-immunized NZM mice revealed increases in the mesangial matrix and evidence of severe glomerulosclerosis without interstitial inflammation and red blood cells in the extra-capillary space; such degenerative changes were not observed in the kidneys of IFA-immunized NZM mice, or Hb- and IFA-immunized FVB mice (Figure 7D). This evidence concerns the gene GSTM1 and glomerulosclerosis.