Suppressor of cytokine signaling 1 (an inhibitor of Stat1 and Stat3 activation) deficient DCs are believed to contribute toward the generation of autoantibodies in vivo (40), while some of the effects of embelin (an anti-inflammatory and pro-apoptotic compound) in experimental autoimmune encephalomyelitis may be mediated by the inhibition of Stat3 in DCs (41). This evidence concerns the gene SOCS1 and experimental autoimmune encephalomyelitis.