fail to induce tumor necrosis factor alpha (TNF-α) (19), whereas Omp25 null mutants of Brucella suis (Δomp25 B. suis) exhibit the ability to activate human macrophages to secrete TNF-α, suggesting that Omp25 is involved in inhibition of TNF-α production during infection of human macrophages (20). The gene discussed is SYNJ2BP; the disease is infection.