Decreased BDNF levels have been associated with psychiatric and neurological disorders including anxiety, depression and Alzheimer’s disease (Phillips et al., 1991; Chen et al., 2006; Bocchio-Chiavetto et al., 2010), as well as emotional exhaustion and burnout (Onen Sertoz et al., 2008). The gene discussed is BDNF; the disease is major depressive disorder.