In addition, ASIP1 overexpression working at central MC4R in transgenic zebrafish model results in enhanced feeding, feed efficiency, weight and linear growth but not in obesity (Guillot et al., 2016), in a similar way to the AgRP1 transgenic zebrafish (Song and Cone, 2007). The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.