ZFHX4 and esophageal squamous cell carcinoma: As ZFHX4 mutations significantly contributed to poor survival of Chinese ESCC patients, we further examined the prognostic role of ZFHX4 mutations in 12 cancer types investigated by TCGA including ESCC and esophageal adenocarcinoma (EAD) of Vietnam, Brazil, United States and other populations19.