As shown in Supplementary Fig. 3, expression of ZFHX4 was significantly up-regulated in Chinese ESCC11, LUAD and LUSC21, 22, and was down-regulated in BRCA, LIHC, rectum adenocarcinoma (READ) and stomach adenocarcinoma (STAD)23–25. Here, ZFHX4 is linked to rectum adenocarcinoma.