Recently, ER stress has been suggested to importantly contribute to the development of insulin resistance, which is sensed by a number of factors, such as, inositol-requiring enzyme-1α (IRE-1α), protein kinase RNA-like endoplasmic reticulum kinase (PERK), and activating transcription factor-6 (ATF-6), and leads to translational attenuation and cellular dysfunction9. Here, ATF6 is linked to Insulin resistance.