NFKB1 and breast carcinoma: Park and colleagues reported that constitutive NF-κB activity in breast cancer cells was crucial for the bone resorption characteristic of the osteolytic bone metastasis via transcriptionally regulating granulocyte macrophage-colony stimulating factor (GM-CSF) that mediated osteolytic bone metastasis of breast cancer by stimulating osteoclast development [20].