NFKB1 and posterior cortical atrophy: To investigate the underlying mechanism of the pro-bone metastasis role of miR-210-3p in PCa, a gene set enrichment analysis of miR-210-3p expression against the oncogenic signatures collection of the MSigDB was performed and the result showed that miR-210-3p overexpression significantly and positively correlated with NF-κB signaling (“JAIN_NF-κB_SIGNALING”) (Additional file 7: Figure S3a).