AGTR1 and Hypertension: Thus, it may be suggested that the inhibition of the enhanced expression of AT1 receptor, enhanced oxidative stress and downstream signaling pathways induced by SNAP may contribute to the attenuation of increased expression of Giα proteins and thereby hyperproliferation of VSMC from SHR and that elevating the intracellular levels of NO in SHR may have protective effect against oxidative stress-induced vascular complications of hypertension.