Impaired function of the manganese transporter SLC30A10 has been implicated in HMDPC (hypermanganesemia with dystonia, polycythemia, and cirrhosis), an early-onset metabolic disorder clinically characterized by increased systemic Mn levels, neurological impairment, polycythemia, and hepatic injury. The gene discussed is SLC30A10; the disease is cirrhosis - dystonia - polycythemia - hypermanganesemia syndrome.