For example, in the No-Screening scenario, a child with severe visual, cognitive, and hearing impairment (Terminal node #14 in Fig 1) will incur the following costs (assuming symptoms at birth that lead to testing, treatment, and follow-up care): 5 infant IgG tests, 5 infant IgM tests, pediatric treatment, CBC, ECG, cranial ultrasound, and 17 funduscopies, as well as the direct costs and productivity losses for child and parents associated with severe visual, cognitive, and hearing impairment, and special education costs. This evidence concerns the gene CD40LG and Hearing impairment.