Thus we provide mechanistic insights into hypoxia-driven invasion and identify a new protein complex for targeting tumor progression, especially since recent reports have demonstrated a critical role of invadopodia during the extravasation step of metastasis.24 Furthermore, CAIX-specific inhibitors are in clinical trials (www.Clinicaltrials.gov, ID # NCT02215850) and, therefore, our findings identify tumor invasion as a new target for these compounds. This evidence concerns the gene CA9 and neoplasm.