Beside, recent study showed that aspirin inhibits G6PD activity in CRC cells through acetylation.32 Additionally, a novel clinical-stage radiosensitizer and chemosensitizer RRx-001 exerts the anti-proliferative effects through inhibiting G6PD activity in human tumor cells.33 Future study should focus on the development of selective inhibitors for G6PD and the combinatorial effects with clinical chemotherapy drugs. The gene discussed is G6PD; the disease is colorectal carcinoma.