PDK4 and melanoma: While PDHK4 is negatively regulated by miR-211 leading to an inhibition of invasion in melanomas,46 another study has demonstrated that upregulation of miR-182 in two lung cell lines is correlated with PDHK4 downregulation and cell growth promotion.47 These opposing roles of PDHK4 in tumorigenesis may depend on tumour’s tissue of origin and the complexity of the genetic background.