Some studies have shown that TGFβ2 can promote the expression of CREB1 in tumor cells through activating the TGFβ receptor and form a self-activating loop.24, 25 In addition to our findings on the SRGN-TGFβ2 loop, we find that TGFβ2, but not TGFβ1, may have a crucial role in TNBC. The gene discussed is CREB1; the disease is neoplasm.