IL6 and pancreatic neoplasm: In addition to IL-6, hypoxia also induces MUC1-C accumulation in pancreatic cancer cells, in turn driving hypoxia-driven angiogenesis.36 Consistent with this report, subjecting AsPC-1 cells to hypoxic conditions led to MUC1-C upregulation in a time-dependent manner, which could be reversed to the basal level by T315 treatment (Supplementary Figure S2).