BTRC and neoplasm: To identify the E3 ligase responsible for ILK inhibition-induced MUC1-C degradation, we turned our attention to Fbw7 (F-box and WD repeat domain-containing 7; aka, Fbxw7) and β-TrCP in light of their tumor-suppressive activities in facilitating the degradation of oncogenic proteins.40 Accordingly, we analyzed the effects on MUC1-C expression when we depleted Fbw7 in SW1990 cells and β-TrCP in AsPC-1 cells, considering the endogenous levels of these E3 ligases in these two cell lines.