For the essential roles of the members in miR-200 family on regulating EMT and the invasion of cancer cells via inhibiting the expression of ZEB1 and ZEB2, a study by Li et al.44 found that miR-200 repressed the metastasis of breast cancer through a moesin-dependent pathway.45 Sundararajan et al.46 found that TSK5 and MYLK, novel molecules in the formation of invadopodia, regulated the invasive behavior of breast cancer cells, which were mediated by the feedback loop of ZEB1/miR-200. The gene discussed is ZEB2; the disease is breast cancer.